| abstract |
The present invention relates to the amino acid derivatives of formula I wherein R1 is -COOR10, -CONHOR10, -CONHNHR10, - (CH2) nSR50 or -YP (OR51) 2, wherein R10 is preferably hydrogen, n = 0- 3, R50hydrogen, alkyl, phenyl, alkylcarbonyl, benzoyl, mercapto, alkylthio, phenylthio, R51 hydrogen, alkyl or phenyl, and Y, methylene or oxygen; R 2, R 3, R 4, R 5, R 6 and R 7 are optionally substituted and / or alkyl, alkenyl, bonded via oxygen, sulfur or nitrogen or carbonyl, and a carbocyclic or heterocyclic group, or two of the alkylalkyl groups, respectively, which form a ring; with the addition that R2 may also be 2-propynyl; R8 is preferably hydrogen or alkyl; R9 is an optionally substituted alkyl or alkoxy group, and a carbocyclic or heterocyclic group which is attached directly to the carbonyl group via an oxygen, sulfur or nitrogen atom; and optionally a double bond, and their salts, as active ingredients, are contained in pharmaceutical compositions, and processes for their preparation. HE |