http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0100469-A2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07b71571160c289fbf5fc680dfea513f |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2018 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2059 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2077 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-44 |
filingDate | 1998-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3543513b3cc4d0a19215b8ff281147a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d184d53d08ff8382fab1e8d10f2867b |
publicationDate | 2001-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | HU-0100469-A2 |
titleOfInvention | A method of making bile-dispersible tablets |
abstract | The present invention relates to a fast-dispersing tablet formulation containing pharmaceutical active ingredients, which tablet formulation has a structure of compressed granules; the granules comprise an active ingredient together with a combination of a waxy substance and a strong sweetener and / or a flavoring agent, a pharmaceutically acceptable carrier selected from or consisting of xylitol, mannitol, maltodextrin or sorbitol, and optionally a flavoring agent and a disintegrant; ; the granules are compressed together with the following extragranular components into a tablet form: a disintegrant, a sweetener and / or a masking agent, and a pharmaceutically acceptable carrier selected from xylitol, mannitol, maltodextrin or sorbitol, or a combination thereof. The invention also relates to a process for the preparation of the above tablet formulation, which comprises preparing A-flavored granules by (i) mixing at least one pharmaceutically active ingredient with one or more pharmaceutically acceptable carriers selected from xylitol, directly compressible mannitol, maltodextrin or sorbitol; a waxy substance; a strong sweetener or flavoring agent; and optionally a disintegrant and a flavoring agent; and (ii) preparing the mixture of step (i) by dry granulation (e.g. conventional dry granulation or roller compaction), grinding and sieving for compression; and B preparing rapidly dispersible tablets by (iii) mixing the product of step (ii) with additional pharmaceutically acceptable carriers comprising xylitol, mannitol, maltodextrin or sorbitol; and optionally a flavoring agent, a sweetening agent / flavoring agent and a disintegrant; and (iv) compressing the mixture of step (iii) into tablets. SHE |
priorityDate | 1997-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 125.