| abstract |
The present invention relates to compounds of formula (I), which is a narrower group of compounds of formula (II), stereoisomers and pharmaceutically acceptable salts thereof, which are predominantly active compounds, wherein A is -CO 2 H, -CH 2 CO 2 H, or -CONHOR5; ring C is fused to ring G; Ring C is a phenyl ring or an aromatic heterocycle containing heteroatoms selected from oxygen, nitrogen or S (O) p, and Ring C substituted with 1 R 1 '; ring G is a carbocyclic ring substituted with 0-1 carbonyl; alternatively, ring G is a heterocyclic ring containing 1-2 heteroatoms selected from oxygen or NRa, substituted with 0-2 carbonyl groups, and has 0-1 double bonds; The compounds of the present invention inhibit metalloproteinase enzymes, tumor necrosis factor and aggrecanase enzyme and are therefore expected to be useful in the treatment or prevention of diseases mediated by these enzymes. In the treatment of such diseases, the treatment and prevention of inflammatory diseases, rheumatoid arthritis, osteoarthritis and tumor metastases are of particular importance. The present invention also relates to pharmaceutical compositions containing the above active ingredients and to their use in the manufacture of medicaments for the treatment of the above diseases. HE |