abstract |
The present invention relates to a compound of formula (I) wherein R1, R2, R3 and R4 in formula (I) are hydrogen, halogen, hydroxy, nitro, cyano, formyl or optionally substituted alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclic, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl -, amino, acylamino, alkylamino, arylamino, aralkylamino, aminoalkyl, alkoxycarbonite, aryloxycarbonite, aralkoxycarbonite, alkoxyalkyl -, aryloxyalkyl, aralkoxyalkyl, alkylthio, thioalkyl, alkoxycarbonite-amino, aryloxycarbonite-amino, aralkoxycarbonite-amino, carboxylic acid or its derivatives, sulfonic acid group or derivatives thereof; The ring is a 5-6 membered carbon ring optionally substituted with one or more heteroatoms, X is oxygen or sulfur or NR9, Ar is an optionally substituted divalent monocyclic or fused, aromatic or heterocyclic group; R5 is hydrogen, halogen, hydroxy, alkoxy, alkyl, optionally substituted aralkyl, or forms a bond together with adjacent R6; R 6 is hydrogen, halogen, hydroxy, alkoxy, alkyl, acyl, optionally substituted aralkyl, or together with R 5 forms a bond; R7 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, alkoxycarbonite, aryloxycarbonite, alkylaminocarbonite, arylaminocarbonite, acyl, heterocyclic, heteroaryl or heteroaralkyl; R8 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heterocyclic, heteroaryl or heteroaralkyl; Y is oxygen or NR10; n is an integer from 1 to 4; m is 0 or 1. The compounds of the invention have hypolipidemic, antihyperglycaemic activity. SHE |