| abstract |
The present invention relates to alatrofloxacin mesylate, which is substantially free of less polar contaminants and is a naphthyridone-type antibiotic, to parenteral pharmaceutical compositions containing these altrofloxacin mesylate as active ingredients, and to methods for purifying alatrofloxacin mesylate. In the purification of the compound of formula (I), the crude reaction product, which contains the compound of formula (I) and less polar contaminants, is treated with a hydrophobic resin. The present invention also provides compounds of formulas (II) and (III), antibacterial compositions comprising any of these compounds, and methods of treating antibacterial infections using a compound of formula (II) or (III), respectively. SHE |