| abstract |
The present invention relates to DNA sequences encoding a human or murine APRIL ligand, fragments and homologues, to the expression of these DNA sequences in their transformed hosts, and to amino acid sequences encoded by nucleic acids and antibodies raised to proteins. While APRIL-encoding mRNAs are present in small amounts in normal tissues, large amounts of mRNAs have been detected in many tumor cell lines. Pharmaceutical compositions containing or derived from nucleic acids, peptides or antibodies according to the invention for preventing or reducing the severity of an autoimmune disease, immune response to a tissue graft; stimulating or suppressing the immune system; inhibiting tumorigenesis; Identifying an APRIL ligand receptor; treating an APRIL ligand-related disorder in a mammal; stimulating cell growth; sejtpusztulásindukálására; It is used to treat, suppress or alter the immune response affecting the signaling pathway between the APRIL ligand and its receptor, preferably in adenocarcinoma cells. SHE |