| abstract |
The present invention relates to compounds of formula I wherein R 1 is hydrogen or carboxyl protecting group, R 2, R 5, R 6 and R 7 are each hydrogen or hydroxy, R 3 and R 4 are each hydrogen or are combined to form an epoxy group or form a single bond, R 8 and R9 is optionally substituted aryl and X is a single bond or methylene, in addition R2 and R3 may be combined to form a single bond, provided that when R2, R5, R6 and R7 are each hydrogen, then R3 and R4 being combined to form an epoxy group; when R3 and R4 are so combined to form a single bond, at least one of R5, R6 and R7 of R2 is hydroxy and the other (or other) is hydrogen; and when R3 and R4 are each hydrogen, then at least one of R2, R6, R6 and R7 is hydroxy and the other (or other) is hydrogen and X is methylene or a salt thereof, for preparing a process, pharmaceutical compositions containing the compounds, and pharmaceutical compositions. SHE |