http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0003578-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ff2d78578d95d1e8d3a2233c76188d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 |
| filingDate | 1998-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6ab2f332f3fea1f02818e468eaa45f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ece036356b1bbfc5c059685bddf136bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bc8acf5b2438cae071771a3acc0e2cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f186cb79a6af018a6837d4f6b3694fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd6c2630301f634a4febc8821e1858bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b37c275415bf2dd75f29f1fd20cd2e9c |
| publicationDate | 2001-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0003578-A2 |
| titleOfInvention | A method for preparing epoxide intermediates for prostaglandins |
| abstract | The present invention relates to a process for the preparation of novel epoxide intermediates of formula (I) for the preparation of 13,14-dihydro-prostaglandin derivatives A, E and F, wherein R is alkyl, carbocyclic aliphatic, heterocyclic aliphatic, aromatic or heteroaromatic; R 'is hydrogen, alkyl, carbocyclic aliphatic, heterocyclicaliphatic, aromatic or heteroaromatic, with the proviso that only one heteroatom is attached to 15-C; and Q is a suitable protecting group. New methyl (7-2-hydroxy-5- [2- (2-oxiranyl) ethyl] from commercially available methyl 7- (3- (R) -hydroxy-5-oxo-1-cyclopentylheptanoate) -4- (1,1,2,2-tetramethyl-1-silapropoxy) -cyclopentyl) -heptanoate can be readily coupled to O-, S- and N-containing nucleophiles in the presence of base or Lewis acid, and the products can be easily ring-opened compared to known lengthy processes 13,14-dihydroprostaglandin derivatives A, E and F can be prepared |
| priorityDate | 1997-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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