abstract |
The present invention relates to compounds of formula (I) which are endothelin antagonists, to processes for their preparation, to synthetic intermediates used in these processes, and to compositions having endothelin antagonist activity, wherein Z is -C (R 18) (R 19) - or -C (O) - wherein R 18 and R 19 is H or alkyl; n is 0 or 1; R is - (CH 2) m -W where m is from 0 to 6. HE |