abstract |
The present invention relates to antibacterial compounds represented by the general formula (1): wherein A and B are independently fused rings which are monocyclic or polycyclicocycloalkyl, cycloalkenyl, aryl and heterocyclic rings having 4 to 8 carbon atoms in the ring structure; X is = CR-, = N-, = N (O) -, = P or = As; Y is = CR2, = NR, -O, = PR, -S, -AsR- or = Se; R, R1, R2 and R3, at each occurrence, are independently hydrogen or halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxy, silyloxy, amino, nitro, sulfhydryl, alkylthio, imine, amide, phosphoryl, phosphonate, phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl , nitrile, guanidine, amidine, acetal, ketal, amine oxide, aryl, heteroaryl, azide, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiourea, urea, thiourea or - (CH2) m-R80; R4 and R5 at each occurrence are independently halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxy, silyloxy, amino, nitro, sulfhydryl, alkylthio, imine, amide, phosphoryl, phosphonate. , phosphine, carbonyl, carboxyl, carboxamide, anhydride, silyl, thioalkyl, alkylsulfonyl, arylsulfonyl, selenoalkyl, ketone, aldehyde, ester, heteroalkyl, nitrile, guanidine, amidine , acetal, ketal, amine oxide, aryl, heteroaryl, azide, aziridine, carbamate, epoxide, hydroxamic acid, imide, oxime, sulfonamide, thioamide, thiocarbamate, urea , thiourea or - (CH2) m-R80; rings A and B are independently substituted or unsubstituted with R4 and R5, the number of substituents being within the limits of stability and valence rules; R80 is unsubstituted or substituted aryl, cycloalkyl, cycloalkenyl, heterocyclic or polycyclic; and m is an integer from 0 to 8, inclusive. SHE |