| abstract |
The present invention relates to novel compounds of formula (1.0) having farnesyl protein transferase inhibitory activity - wherein the dashed line represents a double bond optionally present, and is preferably an nitrogen atom or an N-oxide oxidized nitrogen atom; Rb and Re are hydrogen, Ra, Rc and Rd are halogen; Rf is - (CH2) n-R15 wherein n = 0-8 and R15 is optionally substituted carbamoyl, sulfamoyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R is hydrogen, valeryl, methylsulfonyl, (2-methoxyethoxy) acetyl or methoxyacetyl, N-butyl, N-cyclohexyl or N- (cyclohexylmethyl) carbamoyl, (N-oxopyridyl-3-yl) acetyl or 3-cyclohexylpropionyl; and a hydrogen atom or an oxo group and its salts, which are pharmaceutical preparations containing them. SHE |