| abstract |
The present invention relates to extremities of formula (I) wherein: a) R1, R2 and R3 are hydrogen; unsubstituted alkyl, alkenyl or alkynyl, cycloalkyl, cycloalkenyl, unsubstituted alkylthio or alkoxy, hydroxy, mercapto, nitro, cyano, amino, alkylamino, dialkylamino, or halogen ; b) R 4 is hydrogen; unsubstituted alkyl, amino, hydroxy, mercapto, unsubstituted alkylthio or alkoxy; alkylamino or dialkylamino, or halogen; c) R5 is hydrogen or alkyl or absent; d) where R5 is absent, (a) the bond is a double bond; and e) the [(2-imidazolidinylidene) amino] group is attached to the 5 or 6 position of the benzoxazole - and contains the enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides, and the use of the compounds for the prevention or treatment of disorders modulated by α2-adrenoceptors. SHE |