http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0002758-A2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-618 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06 |
| filingDate | 1997-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e545fbc45e20a8a5c2f9d66b1032a51d |
| publicationDate | 2000-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0002758-A2 |
| titleOfInvention | Non-steroidal ligands for estrogen receptor |
| abstract | The present invention relates to compounds of formula (I) wherein R1 is - (CH2) nCR5 = CR6R7, - (CH2) mC (X) NR8R9, or (A) general, R2 and R3 are hydrogen, methyl, hydroxy, methoxy. - ethoxy or isopropyl, R4 is cyano; nitro, methyl, or ethyl or -CH2 CH2Y or -Y, R5 and R6 are hydrogen, C1-C4 alkyl, C2-4 alkenyl or alkynyl, C3-C3 alkyl, X-2-4 C1-6 alkenyl or alkynyl or -Y, R7 is cyano, C1-4alkylhydroxy, -C (O) O (CH3) 3 or -C (O) NR10R11, -C (O) NR12R13, C 1 -C 4 alkyl -NR 10 R 11, -C (O) R 12, -C (O) OR 12 -C (O) NR 12 OR 13, -C (O) NHC (O) R 12, -C (O) NHCH 2 R 12, -C ( NH2) (NOR12), -S (O) R12, -S (O) (O) (OR12), -S (O) (O) (NHCO2R12), PO3R12, P (O) (NR12R13) (NR12R13), -P (O) (NR12R13) (OR14), -CONR12 (CH2) qOCH3, -CONR12- (CH2) qNR8R9, or a methyl-substituted oxadizole group, R8 and R9 are hydrogen, C1-7alkyl, 3- C 7 -cycloalkyl, -O-C 1-7 -alkyl, C 1-7 -alkyl-Y or phenyl; R10 and R11 are methyl or ethyl or together form a morpholino group attached to the nitrogen atom, R12, R13 and R14 are hydrogen, C1-C12 alkyl, C2-C12 alkenyl or alkynyl, -O-C1-12 alkyl, -O C2-C12 alkenyl or alkynyl, C3-7cycloalkyl or cycloalkenyl, linear or cyclic heteroalkyl, aryl or heteroaryl, or -Y, X is O or S, Y is halogen, n is 0, 1 or 2, m is 1 or 2, p is 1, 2, 3 or 4, and q is an integer from 1 to 12. The invention also relates to the use of the compounds of formula (I) for the prevention or treatment of osteoporosis, cardiovascular diseases, arthritis and breast cancer. HE |
| priorityDate | 1997-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.