| abstract |
The present invention relates to piperazine derivatives of formula (I) wherein R1 is unsubstituted or mono- or di-halogen, CN, A-, AO-, HO-, -CONH2, -CONHA, -CONA2, -COOH, -COOA, -CH2OH, Indol-3-yl substituted with -CH2OA, -CH2NH2, -CH2NHA and / or -CH2NA2, R2 is unsubstituted or mono- or di-halogen, A-, AO-, -OH, CN, -NO2, -NH2, -NHA , -NA2, -COA, -CONH2, -CONAH, -CONA2, -CH2OH, -CH2OA, -CH2NH2, -CH2NHA, -CH2NA2, -COOH and / or -COOA-substituted 2-oxo-2H-1-benzopyran-6 -Il or 2-oxo-2H-1-benzopyran-4-yl, Hal is fluorine, chlorine, bromine, or iodine, A is straight or branched, C 1 -C 10 alkyl having 1 to 5 fluoro- and / or may be substituted with chlorine, or is a C3-C10 cycloalkyl group, to a degree of 2, 3 or 4. The compounds affect the serotoninergic transmission. HE |