abstract |
FIELD OF THE INVENTION The present invention relates to oral pharmaceutical compositions containing an anti-ulcer drug and to a process for their preparation. The pharmaceutical compositions of the present invention include (a) inert cores; (b) a water-soluble or water-rapidly disintegrating layer on the seeds comprising, in addition to a pharmaceutically acceptable excipient (s), a compound of formula (I), formula (II) or formula (III); and (c) an outer coating resistant to gastric conditions, which is an enteric coating polymer; and - at least one excipient. The pharmaceutical compositions of the present invention are prepared by coating the inert cores by spraying a single aqueous or aqueous alcoholic suspension solution; drying the sprayed active layer; and, in order to form a coating resistant to gastric conditions, the core having the active layer is coated by spraying a solution containing at least one pharmacologically acceptable excipient in addition to an enteric polymeric coating material. SHE |