http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0002431-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d16a6ad35d3f1a9f1553bccaccb6c7d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-10 |
| filingDate | 2000-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5112897ecff20dde001d653d5c49a8e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9595fad40cf142f0c91182674d8db67a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b8617fc3663fe9b4684057cb240071a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a7c75239ce3efc5711fd5b056201db4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a112d7d1c813fade5491b501e37dda62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2531991e2227aede5b6e196e9a69aea5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b0254b1f0800dcdfd69625d8b2351aa |
| publicationDate | 2002-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0002431-A2 |
| titleOfInvention | Process for producing omperazole and magnesium carbonate hydroxyd double salt in notstoichiometric portio and pharmaceutical compositions containing it |
| abstract | Preparation of a novel non-stoichiometric solid-phase addition compound, omeprazole-magnesium-carbonate-hydroxide (pharmacopoeia name), comprises e.g.: preparing magnesium-dihydroxy-tricarbonate by adding to one mole of omeprazole, a quantity equivalent to 0.5-2.0 Mg-ions taken from a double salt prepared according to the rules of the pharmacopoiea, and containing 22.5-25.4 Mg ions. Preparation of a novel non-stoichiometric solid-phase addition compound, omeprazole-magnesium-carbonate-hydroxide (pharmacopoeia name), comprises: preparing magnesium-dihydroxy-tricarbonate by adding to one mole of omeprazole, a quantity equivalent to 0.5-2.0 Mg-ions taken from a double salt prepared according to the rules of the pharmacopoiea, and containing 22.5-25.4 Mg ions. The preparation is conducted in the presence of an organic solvent or a mixture of solvents, preferably 0.3-0.5 pts.wt. of 96% ethanol, with kneading and agitation of the heterogeneous phase. The preparation is allowed to stand for 30 minutes prior to granulation followed by drying to constant weight at 40 [deg]C and final regranulation. This non stoichiometric omeprazole magnesium-carbonate-hydroxide is formulated with excipients to form enterosolvent film-coated acid resistant capsules, tablets or uncoated rectal preparations. |
| priorityDate | 2000-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.