http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0002114-A2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate | 1998-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b131f49ec5db9f676f1aae9d156eff5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3986f874070810e64ef98de976c649bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ece25d67c716dd679b829bd1d87dd2bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce424c44e41648fc7da3541a711459c9 |
| publicationDate | 2000-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0002114-A2 |
| titleOfInvention | Process for the preparation of 5'-deoxy-5-fluorouridine |
| abstract | The present invention relates to a process for the preparation of doxifluridine of formula (I) in which 2 ', 3'-O-isopropylidene-5-fluorouridine of formula (II) is reacted with a sulfonic acid of formula (III) R-SO3H (III) - wherein R is reacted with an alkyl derivative of alkyl, trifluoromethyl, phenyl or mono-, di- or trisubstituted phenyl; (b) reacting the 5 '- (sulfonyloxy) derivative of the general formula (IV) thus obtained with an alkali metal or alkaline earth metal iodide; (c) hydrolyzing the resulting 5'-deoxy-5'-iodo-2 ', 3'-O-isopropylidene-5-fluorouridine of formula (V) in an acidic medium; and (d) reducing the 5'-deoxy-5'-iodo-5-fluorouridine of formula (VI) with hydrogen or a hydrogen donor. SHE |
| priorityDate | 1997-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.