| abstract |
The present invention relates to alternatively targeted adenoviruses, to methods for producing and purifying such viruses, and to protein alterations that allow such alternative delivery. More particularly, the present invention relates to a trimer particle comprising three monomers, each containing the amino terminus and a trimerization domain of the adenovirus fiber protein. The trimer exhibits lower affinity for native substrate than native adenovirus fibertrimers. The invention further provides adenovirus and modified pentone comprising the trimer of the invention. In addition, the present invention provides a cell line expressing a non-native cell surface receptor to which adenoviruses carrying the areceptor ligand bind, and methods for propagating adenoviruses using the cell line. The present invention provides methods for treating and preventing adenovirus infections. SHE |