| abstract |
The present invention relates to novel thiazole benzene sulfonamides of the general formula (I) as agonists for the treatment of obesity and diabetes and to pharmaceutical compositions containing them. The compounds are <3 adrenergic receptor agonists, which exhibit very little <1 and <2 adrenergic receptor activity, and are therefore useful for increasing lipolysis and energy consumption in cells. Thus, the compounds are effective II. type diabetes and obesity. The compounds may be used to lower triglyceride levels, lower cholesterol, or increase high density lipoprotein levels, reduce bowel movement. In addition, the compounds may be used to reduce neurogenic inflammation or as an antidepressant agent. HE |