| abstract |
The present invention relates to 5,6,7-trisubstituted-4-aminopyrido [2,3-d] pyrimidine compounds of formula II wherein R 1 and R 2 independently of one another are hydrogen, lower alkyl, arylalkyl. or an acyl group or together with the linker nitrogen forms a 5-7 membered ring optionally containing from 1 to 3 further heteroatoms selected from the group consisting of nitrogen, oxygen and / or sulfur; R3 and R4 are independently selected from the group consisting of lower alkyl, alkenyl, alkynyl or cycloalkyl, aryl, arylalkyl, heteroaryl or heterocyclic; and R5 is aryl, heteroaryl or heterocyclic; and pharmaceutical compositions comprising adenosine kinase inhibitors containing the compounds in a pharmaceutical amount and a pharmaceutically acceptable carrier. The above compounds are thus useful in the manufacture of a medicament for the treatment of ischemia, epilepsy, pain, sensation of pain, inflammation and sepsis. The invention also relates to the preparation of compounds. HE |