| abstract |
The present invention relates to pharmaceutically acceptable salts of the compounds of formula I wherein Ar1 is a 5- or 6-membered aromatic or heteroaromatic ring and a carbocyclic or heterocyclic group consisting of two or three rings; Ar 2 is quinolyl, styryl, thienyl, furyl, isoquinolyl, pyrrolyl, benzofuryl, pyridinyl, thianaphthyl or indolyl, and pharmaceutical compositions containing them. These salts and compositions are preferably used to influence the activity of endothelin peptides and, as such, are useful in the treatment of endothelin-mediated diseases and disorders. Among these diseases are high blood pressure, cardiovascular disease, asthma, pulmonary hypertension, inflammatory diseases, eye diseases, menstrual disorders, obstetric conditions, wounds, intestinal disorders, renal insufficiency, immunosuppressive, mediated vasoconstriction, endotoxin shock, anaphylactic shock, and bleeding shock. SHE |