| abstract |
The present invention relates to compounds of formula (I), pharmaceutical compositions containing them. The compounds of the invention are useful for inhibiting the release and / or formation of b-amyloid peptides in cells, and are therefore useful in the treatment or prevention of various diseases, including Alzheimer's disease. In general formula (I), the substituents are, inter alia, R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted cycloalkyl, substituted cycloalkenyl, substituted cycloalkenyl, substituted cycloalkyl, substituted cycloalkenyl, substituted cycloalkyl, substituted cycloalkenyl, substituted cycloalkyl, substituted cycloalkenyl. aryl, heteroaryl or heterocyclic; W is, inter alia, a -C (H) pC (= X) --cycloalkyl, cycloalkenyl, heterocyclic, substituted cycloalkyl or substituted cycloalkenyl group, which in each case may be substituted or condensed to form a two or more ring system; X is oxo, thioxo, hydroxyl, thiol or hydrogen; Y is a group of the formula wherein R2 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclic, which may optionally be substituted; Z is -T-CX'X "C (O) -, wherein T is a covalent bond to which R 1 is attached to a -CX 'X" group, oxygen atom, sulfur atom, -NR 5 wherein R 5 is hydrogen, acyl, alkyl , aryl or heteroaryl; X 'is hydrogen, hydroxy or fluoro; X '' is hydrogen, hydroxy or fluoro or X 'and is an oxo group; m is 0 or 1; n is 0, 1 or 2; p is 0 or 1 bound to certain conditions. HE |