| abstract |
The present invention relates to compounds of the formula I in which R 1 is hydrogen, hydroxy, C 1 -C 16 -alkyl, C 1 -C 16 -alkoxy, C 3 -C 8 -cycloalkyloxy, halogen, optionally acyl, trifluoroacyl -amino, mono-or disubstituted with aralkyl or aryl, -OSO2 (R4), R2 is hydrogen, RB-CH2-, C1-C16-alkyl, C3-C8-cycloalkyl, aryl- C 16 alkyl, aryloxyC 1-6 alkyl, -C (R 5) = O acyl, an amino acid acyl group, R 3 is -OR 6, -NR 7 R 8, with the proviso that when R1 is methoxy and R3 is hydroxy, R2 is other than (4-pyridyl) methyl, and their pharmaceutically acceptable salts, processes for their preparation, and int relates to a pharmaceutical composition containing an amyloidosis containing the compounds of the invention. HE |