| abstract |
The invention relates to 2-amino-1,2,3,4-tetrahydro-naphthalene hydroxymethyl derivatives as cardiovascular agents. Compounds of Formula (II) are 5, 6, or 7; s is 2 or 3; A is O; R'4, R'5 and R'6 are the same or different and are hydrogen, halogen, hydroxy, nitro, C1-C4 alkyl, C1-4alkoxy, C1-4alkylthio, amino, mono - C 1 -C 4 alkylamino, SH, C 1 -C 4 alkylsulfonyl, C 1-4 alkoxycarbonyl, NHCHO, C 1-4 alkylcarbonylamino, NHCONH 2, 1-4 C 1-4 alkylsulfonylamino, C 1-4 alkylaminosulfonyl, SO 2 NH 2, NHSO 2 NH 2, COOH, SO 3 H, CONH 2, CH 2 OH or phenyl; or R'4 and R'5 are taken together in ortho position to form a chain of 3 or 4 groups, which may be C T'T ", CO, S, O or NT" ', where T' is hydrogen or alkyl of 1-4 carbon atoms, T is hydrogen atom, C 1-4 alkyl or amino, and T "'is hydrogen or C 1-4 alkyl; or T 'forms an adjoining line with adjacent T' or T '', or T 'forms an adjoining line with adjacent T' or T ''; the star denotes an asymmetric carbon atom; and pharmaceutically acceptable salts thereof. HE |