| abstract |
The present invention relates to compounds of general formula (I), their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. In the formula (I), the major ones are: R1 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl. which may be hypersensitive to the administered case, Z is -NR 10 SO 2 -, -SO 2 NR 10 -, -NR 10 C (R 7 R 8) -, -C (R 7 R 8) NR 10 -, -OSO 2 -, -SO 2 O-, -OC (R 7 R 8) -, -C (R 7 R 8) - ) An O-, -NR10CO- or -CONR10- general formula; R2, R3 and R4 independently of one another are hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, heteraryl, trifluoro-methyl, halogen, hydroxyalkyl, cyano, nitro, carboxy , Or, in the case where the R 2 and R 3 pellets are on a paraffin-like carbon atom, they may form a -CH = CH-CH = CH- or - (CH 2) 4 -aryl chain, where q is 2 -6, and R4 is as defined above; Y is a sulfur or sulfur atom, or -NR10 or -CHR10- is a general formula or a stone valent bond; X is an xenograft or -NR9 -modified tuber; R6 is hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, aminoalkylamino (2-10 carbon atoms), dialkylamine (2-10 carbon atoms) alkyl or carboxyalkyl R7, R8, R11 and R12 are independently hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, aminoalkylamino, dialkylaminoalkyl or carboxyalkyl group; or R7 and R8 together form - (CH2) y - form a generic chain wherein y is 0 (pendant), 1 or 2, and R11 and R12 are as defined above; or R7 and R12 together form a (CH2) q-chain, wherein q is 0 (bond) or 1-8, and R8 and R11 are as defined above; or R8 and R11 taken together to form a (CH2) r general chain, wherein r is 2-8 and R7 and R12 are as defined above, Ra, Rb, Rc are independently hydrogen, alkyl, hydroxy, alkyloxy, aryl, hydroxy , aralkoxy, alkyloxycarbonyloxy, cyanobacterium or -CO2RW; According to the invention, the compounds have antithrombotic activity. ŕ |