| abstract |
A compound selected from the group of compounds represented by formula Iu wherein: A is -CH 2 -, -O-, -S-, or -S (O) -; Ar is optionally substituted phenyl or optionally substituted naphthalenyl; R 1 is hydrogen, alkyl, alkoxy, hydroxy, hydroxy-alkyl, alkylthio, halo, cyano, -C (O) R 5, -C (O) NR 5 R 6, -NR 5 R 6, - (CR'R ") 0-3OC (O) R 5 , - ((CR'R ") 0-3SO2R5 and - (CR'R") 0-3NSO2R5, wherein R5, R6, R ', and R "are each independently at each occurrence hydrogen or alkyl, provided that if A -CH 2 -, R 1 is not -C (O) NR 5 R 6, R 2 is hydrogen, alkyl, alkoxy, hydroxy, halo, halo-alkyl, nitro, cyano, or -NR 5 R 6, wherein R 5 and R 6 are as previously defined; R3 is -SOR7, -SO2R7, or -SO2NR5R6 wherein R7 is alkyl, hydroxy-alkyl, alkoxy-alkyl, or alkoxycarbonyl-alkyl; and R5 and R6 are as previously defined; R4 is hydrogen or alkyl; and prodrugs thereof, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts. The patent contains 18 more patent claims. |