| abstract |
A pyrazolopyrimidine compound of formula (I) wherein Y1 represents N or C-, Y2 represents N or C-, Y3 represents N or C-, Y4 represents N or C-, wherein at least two of the groups Y1 to Y4 denote a carbon atom, R1 represents chloro or bromo; R 2 and R 3 each independently represent hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl or trifluoromethyl; or R 2 and R 3 both together with the ring carbon atom represent a carbonyl group; R 4 and R 5 each independently represent hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl or trifluoromethyl; or R4 and R5 together with the ring carbon atom represent a carbonyl group; R6 and R7 separately represent hydrogen, C1-6alkyl, C3-7cycloalkyl or trifluoromethyl; or R 6 and R 7 together with the ring carbon atom represent a carbonyl group, R 2 and R 3 together with R 6 R 7 may also form a bivalent radical from the group CH 2 -CH 2 or CH 2 -O; R10 and R11 independently represent hydrogen, halogen, amino, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, aryl, C1-6alkyl, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, C3-7-cycloalkyloxy, C2 -6alkenyloxy, C2-6alkynyloxy, heteroaryl, heterocyclyl, aryloxy, heteroaryloxy, heterocyclyloxy, C1-6alkylamino, di-C16alkylamino, C3-7-cycloalkylamino, di-C3-7-cycloalkylamino, C1-6alkyl-C2-7 -6alenylamino, C2-6alkynylamino, di-C2-6alkenylamino, di-C2-6alkynylamino, C1-6alkyl-C2-6alkenylamino, C1-6alkyl-C2-6alkynylamino, C2-6alkenyl-C3-7-cycloalkylamino, C2-6alkynyl-C3 -7-cycloalkylamino, C2-6alkenyl-C2-6-alkynylamino arylamino, diarylamino, aryl-C1-6alkylamino, aryl-C2-6alkenylamino, aryl-C2-6alkynylamino, aryl-C3-7-cycloalkylamino, heteroarylamino, diarylarylamino C1-6alkylamino, heteroaryl-C2-6alkenylamino, heteroaryl-C2-6alkynylamino, heteroaryl-C3-7-cycloalkylamino, heteroarylarylamino, heterocyclylamino, diheterocyclylamino, heterocycles 1-C1-6alkylamino, heterocyclyl-C2-6alkenylamino, heterocyclyl-C2-6alkynylamino, heterocyclyl-C3-7-cycloalkylamino, heterocyclylarylamino, heterocyclylhetero-arylamino, acyl, acyloxy, acylamino, C1-6alkyloxycarbonyl 6alkenyloxycarbonyl, C26alkynyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, heterocyclyloxycarbonyl, aminocarbonyl, C1-6alkylaminocarbonyl, di-C1-6alkylaminocarbonyl, C3-7-cycloalkylaminocarbonylcarbonyl 6alkenyl-aminocarbonyl, C2-6alkynylaminocarbonyl, di-C2-6alkenylaminocarbonyl, di-C2-6alkynylaminocarbonyl, C1-6alkyl-C2-6-alkenylaminocarbonyl, C1-6alkyl-C2-6-alkynyl-aminocarbonyl, C2-6alkenyl cycloalkylaminocarbonyl, C2-6alkynyl-C3-7-cycloalkylaminocarbonyl, C2-6alkenyl-C2-6-alkynylaminocarbonyl, arylaminocarbonyl, diarylaminocarbonyl, aryl-C1-6alkylaminocarbonyl, aryl-C2-6alkylaminocarinoyl cycloalkylaminocarbo nyl, heteroarylaminocarbonyl, diheteroarylaminocarbonyl, heteroaryl-C1-6alkylaminocarbonyl, heteroaryl-C2-6alkenylaminocarbonyl, heteroaryl-C2-6alkyl |