| abstract |
A compound represented by the following formula (1), or a pharmaceutically acceptable salt thereof, wherein R 1 represents a halogen atom, an alkenyl group or an alkynyl group; R2 represents a halogen atom or an alkyl group; the alkyl group may be substituted by a hydroxyl group; R3 represents a hydrogen atom or a halogen atom; R4 represents a hydrogen atom, an alkyl group, an alkenyl group or an alkynyl group; the alkyl group, the alkenyl group and the alkynyl group may have one to three substituents selected from the group consisting of -ORa, -NRaRb, -NRaCORb, a heterocyclic group and a heteroaryl group; the heterocyclic group and the heteroaryl group may have one to three substituents selected from the group consisting of a C1-5 alkyl group, -ORa and -NRaRb; X represents a group represented by the following formula (i):? -YZW (i) wherein Y represents -O-, -NR8O-, -ONR8-, -NR8CO- or -NR8SO2-; Z represents a C1-8 alkylene chain, which may be substituted with one to three groups, represented by W '; wherein R8 represents a hydrogen atom, an alkyl group, -ORa or -COR9; the alkyl group may be substituted by a halogen atom, -ORa or -NRaRb; R9 represents a hydrogen atom, an alkyl group or -ORa; the alkyl group may be substituted by a halogen atom, -ORa or -NRaRb; R8 and R9 may be attached to an alkylene chain Z, or form a heterocyclic group by a bond to a substituent represented by Ra or Rb in Wili alternatively, X represents a group represented by the following formula (ii): wherein each of Y1 and Y2, which may be the same or different , represents a single bond, -CO-, -COO-, -O-, -OCO, -NRa- or -SO2-; Z 'represents a C1-5 alkylene chain, which may be substituted by one to three groups, represented by W '; in the above formulas (i) and (ii), each of W and W ', which may be the same or different, represents a C1-5 alkyl group, a halogen atom, an oxo group, -ORa, -COORa, -COOCORa, -CO -halogen atom, -OCORa, -CONRaRb, -SRa, -SORa, -SO2Ra, -NRaRb, -NRaCORb, -NRaSO2Rb, -SO2NRaRb, heterocyclic group or heteroaryl group; the heterocyclic group and the heteroaryl group may have a substituent selected from the group consisting of a C1-5 alkyl group, -ORa and -NRaRb; the alkyl group may be substituted by a hydroxyl group, a C1-5 alkoxy group or an amino group; the above substituents, in addition to the oxo group and the halogen atom, may be attached to each other to form a cycloalkyl group or a heterocyclic group; the cycloalkyl group or the heterocyclic group may have a substituent selected from the group consisting of -ORa, -NRaRb and a C1-5 alkyl group, which may be substituted by -ORa; each of Ra and Rb, which may be the same or different, represents a hydrogen atom or a C1-5 alkyl group; the alkyl group may be substituted with one to three groups selected from the group consisting of a hydroxyl group, a C1-5 alkoxy group and an amino group; provided that when X is the group represented by formula (i) shown above and Y is not -O |