http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HR-P20100416-T1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D411-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 |
| filingDate | 2010-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3895e682c8a30c9b39d62c9046c7886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_193192b85d3c7a2658c82f02b17f251f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_041e23e705fa8a1f64960a1acf58e10e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9e4b002ca8a3ce86e4dc407bb664e61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e5fbacd60d83aa94dec9fdc24a50f4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f9aa5e2571a34c15807b10a2a4ea178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c42f84aaa808a5090bc2b69d1da526cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_092a0d38494cff6fdb8726d949c04db8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec0ead050cf5db694ce5ae0f295853e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_555fc64634101dc356a60ba67b669ee6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca54953994dcdfb591ddc9163b02348d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25dcbbc3ba6c1827a4d364e7427cf734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b43e87d2e3d6d4d04bfbeafe400fbb59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a979893eb17109c1ea051588066f7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e618636647f6e0edd3876c9e5e8b2f8b |
| publicationDate | 2010-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HR-P20100416-T1 |
| titleOfInvention | SULFUR COMPOUNDS AS INHIBITORS OF SERINE PROSTHESAS NS3 HEPATITIS C VIRUS |
| abstract | A compound, or enantiomers, stereoisomers, rotamers, tautomers, and racemates of said compound, or a pharmaceutically acceptable salt or solvate of said compound, wherein said compound has the general structure shown in Formula I: wherein: R 1 is H, OR 8, NR 9 R 10 or CHR 9 R 10, wherein R 8, R 9 and R 10 may be the same or different, each of which is independently selected from the group consisting of H, alkyl-, alkenyl-, alkynyl-, aryl-, heteroalkyl-, cycloalkyl-, heterocyclyl-, arylalkyl-, and heteroarylalkyl; A and M may be the same or different, each of which is independently selected from R, OR, NHR, NRR ', SR, SO2R, and halogen; or A and M are attached together so that the residue: shown above, in Formula I, forms either three-, four-, six-, seven- or eight-membered cycloalkyl, four- to eight-membered heterocyclyl, six- to ten-membered aryl, or five - up to ten membered heteroaryl; E is C (H) or C (R); L is C (H), C (R), CH2C (R) or C (R) CH2; R, R ', R2, and R3 may be the same or different, each of which is independently selected from the group consisting of H , alkyl, alkenyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl, or alternatively R and R 'in NRR' are attached together so that NRR 'forms a four- to eight-membered heterocyclyl; or R 2 is selected from the group consisting of the following residues: a Y is selected from the following residues: wherein G is NH or O; and R15, R16, R17 and R18 may be the same or different, each of which is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or alternatively, (i) R15 and R16 is attached together to form a four- to eight-membered cyclic structure, and (ii) also, independently, R17 and R18 are attached together to form a three- to eight-membered cycloalkyl or heterocyclyl; wherein each of said alkyl, aryl, heteroaryl, cycloalkyl or heterocyclyl may be unsubstituted or optionally independently substituted with one or more radicals selected from the group consisting of: hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, amido, alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, sulfonamido, alkylsulfonamido, arylsulfonamido, alkyl, aryl, heteroaryl, keto, carboxy, carbalkoxy, carboxamido, alkoxycarbonylamino, alkoxycarbonyloxy, alkylureido, alkylureido means an aliphatic hydrocarbon group which may be straight or branched and contains 1 to 20 carbon atoms in the chain; "alkenyl" means an aliphatic hydrocarbon group containing at least one carbon-carbon double bond and may be straight or branched and containing 2 to 15 carbon atoms in the chain; "alkynyl" means an aliphatic hydrocarbon group containing at least one carbon-carbon triple bond and may be straight or branched and contains 2 to 15 carbon atoms in the chain; "aryl" means an aromatic monocyclic or polycyclic ring system having 6 to 14 carbon atoms; "heteroaryl" means an aromatic monocyclic or polycyclic ring system having 5 to 14 ring atoms, in which |
| priorityDate | 2004-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.