abstract |
A compound having the formulas or a pharmaceutically acceptable salt thereof, wherein A is -CH 2 OHO 2; B and C are -OH; D is A and B are trans with respect to each other; B and C are cis one with respect to the other; C and D are cis or trans with respect to each other; R1 is pentyl, isopentyl, neopentyl, hexyl, isohexyl, neohexyl, heptyl, isoheptyl, neoheptyl, octyl, isooctyl, neoctyl, nonyl, isononyl, neononyl, decyl, isodecyl, neodecyl, -aryl, -3- to 7-membered monocyclic , -8- to 12-membered bicyclic heterocycle, -C3-C8 monocyclic cycloalkyl, -C3-C8 monocyclic cycloalkenyl, -C8-C12 monocyclic cycloalkenyl, -C8-C12 bicyclic cycloalkyl, -C8-C12 bicyclic cycloalkenyl, - (CH2) n- (C3-C8 monocyclic cycloalkyl), (CH2) n- (C3-C8 monocyclic cycloalkenyl), - (CH2) n- (C8-C12 bicyclic cycloalkyl), - (CH2) n- (C8-C12 bicyclic cycloalkenyl) , or - (CH 2) n-aryl; R2 is -CN, -NHR4, -NHC (O) R4, -NHC (O) OR4, -NHC (O) NHR4, -NHNHC (O) R4, NHNHC (O) OR4, -NHNHC (O) NHR4, or -NH-N = C (R6) R7; R4 is -C1-C15 alkyl, -aryl, - (CH2) n-aryl, - (CH2) n- (3- to 7-membered monocyclic heterocycle), - (CH2 ) n- (8- to 12-membered bicyclic heterocycle), - (CH2) n- (C3-C8 monocyclic cycloalkyl), - (CH2) n- (C3- to C8 monocyclic cycloalkenyl), - (CH2) n- ( C8-C12 bicyclic cycloalkyl), - (CH2) n- (C8- to C12 bicyclic cycloalkenyl), -C C- (C1-C10 alkyl) or C C-aryl; R6 is -C1-C10 alkyl, -aryl, - (CH2) n-aryl, - (CH2) n- (3- to 7-membered monocyclic heterocycle), - (CHO2) n- (8- to 12-membered bicyclic heterocycle), - (CH2) n- (C3- to C8 monocyclic cycloalkyl), - (CH2) n- (C3-C8 monocyclic cycloalkenyl), - (CH2) n- (C8-C12 cycloalkyl), - (CH2) n- (C8-C12 bicyclic cycloalkenyl), - (CH2) n- (C3-C8 monocyclic cycloalkenyl), -phenylene- (CH2) n-COOH, or -phenylene- (CH2) nCOO- (C1-C10) alkyl; R7 is -H, -C1-C10 alkyl, -aryl, - (CH2) n-aryl, - (CH2) n- (3- to 7-membered monocyclic heterocycle), - (CH2) n- (8- to 12 -Bicyclic heterocycle), - (CH2) n- (C3-C8 monocyclic cycloalkyl), - (CH2) n- (C3-C8 monocyclic cycloalkenyl), - (CH2) n- (C8-C12 bicyclic cycloalkenyl) or (CH2 n- (C8-C12 bicyclic cycloalkyl); and each n is independently an integer in the range from 1 to 5. The patent contains 56 more claims. |