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publicationDate 2010-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber HR-P20100259-T1
titleOfInvention DERIVATIVES OF 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINE, THE PROCEDURE FOR THEIR PREPARATION AND THE PHARMACEUTICAL MIXTURES CONTAINING THEM
abstract Compound of Formula (I): - R 1 represents a hydrogen atom or a group selected from C 3 -C 7 cycloalkyl, benzyl and straight or branched C 1 -C 6 alkyl, an alkyl group saturated or unsaturated and optionally substituted with a hydroxy or C 3 -C 7 cycloalkyl group or with one or more halogen atoms, - R 2, R 3, R 4 and R 5 which may be the same or different, each representing a hydrogen atom or a hydroxy group; methyl group; -OSO2R10 group; -OCOR10 group; or a straight or branched, saturated or unsaturated C1-C6alkoxy group, optionally substituted with a methoxy or - (CO) -NR12R'12 group, or R2 and R3, or R3 and R4, or R4 and R5 together form a group -O- ( CH2) qO-, -O-CH = CH-O or -O-CH = CH -, - R6, R7, R8 and R9, which may be the same or different, each representing a hydrogen atom or a straight or branched saturated or unsaturated C1 -C6alkoxy group, or R6 and R7 or R7 and R8, or R8 and R9 together form a group -O- (CH2) qO -, - R10 represents a group selected from straight or branched C1-C6alkoxy, NR11R'11 and straight or branched C1 -C6alkyl which may be optionally substituted by one or more halogen atoms, - R11 and R'11, which may be the same or different, each represent a hydrogen atom or a straight or branched C1-C6alkyl group, or R11 and R'11 together with the nitrogen atom carrying them forms a monocyclic or bicyclic, 5 to 8 membered nitrogen containing a heterocycle which may optionally have a second heteroatom selected from O and N, said heterocycle being may be optionally substituted by one or more halogen atoms, - R12 and R'12, which may be the same or different, each represent a hydrogen atom or a straight or branched C1-C6alkyl group, - X represents O, NH or CH2, - mip, which may be the same or different, each representing 0 or 1, -niq, which may be the same or different, each representing 1 or 2, their optical isomers when present, and also their addition salts with a pharmaceutically acceptable acid. The patent contains 17 more patent claims.
priorityDate 2007-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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