http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HR-P20100087-T1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 |
| filingDate | 2010-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d7b3586d737f4a651972e04420553a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f725067266fc6b51d7a74952f4e495c |
| publicationDate | 2010-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HR-P20100087-T1 |
| titleOfInvention | ENANTIOSELECTIVE PREPARATION OF QUINOLINE DERIVATIVES |
| abstract | Process for the preparation of 8-substituted oxy - ((R) -2-halo-1-hydroxy-ethyl) - (1H) -quinolin-2-one or acceptable solvates thereof, comprising the reaction of 5- (α-haloacetyl) ) -8-substituted oxy- (1H) -quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form 8- (substituted oxy) -5- (R) -2-halo-1-hydroxy -ethyl) - (1H) -quinolin-2-one, wherein said chiral agent has the formula I or II wherein M is Ru, Rh, Ir, Fe, Co or Ni; L is a C6-C24-aryl or C6-C24-aryl-C1-C10-aliphatic residue, which in both cases is optionally attached to a polymer; X is hydrogen or halo; R1 is a C1-C10-aliphatic, C3-C10-cycloaliphatic, C3-C10-cycloaliphatic-C1-C10-aliphatic, C6-C24-aryl-C1-C10-aliphatic residue or a 4- to 12-membered heterocyclic group which is in in each case optionally linked to a polymer; and R2 and R3 are phenyl; or R2 and R3 together with the carbon atom to which they are attached form a cyclohexane or cyclopentane ring. The patent contains 9 more patent claims. |
| priorityDate | 2004-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.