http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HR-P20090535-T1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-13 |
| filingDate | 2009-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f98dd86a4916368c5889d9df701aab67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee87f0968f13b534a14230e0c9a7bc59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c372270badc61055ed43c3883f15f247 |
| publicationDate | 2009-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HR-P20090535-T1 |
| titleOfInvention | USE OF MODIFIED CYCLOSPORINS FOR TREATMENT OF HCV DISORDERS |
| abstract | Use of cyclosporin for the preparation of a pharmaceutical composition for the prevention or treatment of hepatitis C infection or HCV induced disorders, wherein cyclosporin (i) binds to human recombinant cyclophilin with a binding ratio BR of less than 0.7, where BR is the log base 10 of the ratio of IC50 cyclosporin to IC50 cyclosporin A measured in a competitive ELISA assay; and (ii) has an activity in the Mixed Lymphocyte Reaction of not more than 5% cyclosporin A, wherein the cyclosporin is a compound of formula Iau wherein W 'is MeBmt, dihydro-MeBmt or 8'-hydroxy-MeBmt; X is αAbu, Val, Thr, Nva or O-methyl threonine (MeThr); R 1 is Sar, (D) -MeSer, (D) -MeAla, or (D) -MeSer (Oacetyl); Y 'is MeLeu, γ-hydroxy-MeLeu, MeVal, MeThr, MeAla, MeaIle or MeaThr; N-ethylNal, N-ethylIle, N-ethylThr, N-ethylPhe, N-ethylTyr or N-ethylThr (Oacetyl); Z is Val, Leu, MeVal or MeLeu; teQ 'is MeLeu, γ-hydroxy-MeLeu or MeAla, or a pharmaceutically acceptable salt thereof. The patent contains 5 more patent claims. |
| priorityDate | 2003-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.