http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HR-P20090533-T1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 |
| filingDate | 2009-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f904cdc769b07d70bf39b85f2ae53815 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08aa9a0ba83c3b64e64d5fb66a7eaaad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e0d6432f5b9600d394f4b154c2d89fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d0d15d73bfb45e4b8e25d5967a29ef0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83413618aa6a15ca8b99b862f10a8ecf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d2e92cf4711c6a42494f81603f2bd2e |
| publicationDate | 2009-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HR-P20090533-T1 |
| titleOfInvention | DERIVATIVES INDOLILA KAO MODULATORS X-RECEPTOR |
| abstract | Compounds of formula (I), wherein R 1 is hydrogen, alkyl, halogen, formyl, hydroxyalkyl or trifluoromethyl; R 2 is hydrogen, alkyl, alkenyl, alkynyl, cyano or halogen; R3 is hydrogen or alkyl; R4 is hydrogen, alkyl, hydroxy or alkoxy; R 5 and R 6 are independently selected from hydrogen, alkyl, arylalkyl, heteroarylalkyl, hydroxyalkyl, alkoxycarbonyl, aryl and heteroaryl; A is aryl or heterocyclyl, wherein aryl and heterocyclyl are optionally substituted with one to three substituents independently selected from alkyl, halogen, amino, hydroxyalkyl, aryl, aryloxy, alkoxy, arylalkyl, arylalkenyl, alkoxycarbonylamino, aminocarbonyloxy, alkoxycarbonyloxy, carbonyloxy , trifluoromethyl, arylalkylaminocarbonyl, alkoxycarbonylalkylaminocarbonyl, indolylalkylaminocarbonyl, morpholinyl-carbonyl, aminocarbonyl, aminocarbonylalkyl, aminokarbonilalkoksi, alkoxycarbonylalkoxy, piridinilalkilaminokarbonil, alkiloksikarbonilalkilaril, alkiloksikarbonilalkoksiaril, karboksialkilaril, karboksialkoksiaril, aminokarbonilalkilaril, aminokarbonilalkoksiaril, aminocarbonylamino, aminocarbonyloxy, aminokarboniloksiaril, carboxyalkyl, carboxyalkoxy, cycloalkylaminocarbonyl, morpholinylcarbonyloxyaryl, morpholinylcarbonylaryl , arylalkoxyaryl, aminocarbonylaryl, pyrrolidinylcarbonyloxyaryl, pyrrolidinylcarbonylaryl, piperidinylcarbonylaryl, piperidinyl rbonyloxyaryl; hydroxyalkylaryl, hydroxy (carboxy) alkylaryl, hydroxy (alkoxycarbonyl) alkylaryl, hydroxy (aminocarbonyl) alkylaryl and pyridinyl; m is zero, 1, 2 or 3; n is zero or 1; p is zero, 1, 2 or 3; provided that the sum of m, n and p is 1, 2, 3 or 4; and, wherein the compound is not 2- (1-benzyl-2,3-dihydro-1H-indol-5-yl) -1,1,1,3,3,3-hexafluoro-propan-2-ol; and, wherein the bond between the carbon atoms Ca and Cb is a single or double carbon-to-carbon bond and in case the carbon-to-carbon bond between Ca and Cb is double, then R3 and R4 are absent; and, then, when the bond between the carbon atoms Ca and Cb is a single carbon-to-carbon bond and the combination of R 1, R 2, R 3 and R 4 is selected from the group consisting of: R 1, R 3, R 4 = H, R 2 = CH 3; R3, R4 = H, R1, R2 = CH3; R3, R4 = H, R1 = C4H9, R2 = C2H5 and R3 = H, R1, R2, R4 = CH3, - (CH2) m- (CR5CR6) n- (CH2) pA is not where R13 is H, F, Cl , Br, NO2, phenyl or CH3, and pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof. The patent contains another 28 patent claims. |
| priorityDate | 2004-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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