| abstract |
A compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein: X 1 is C E 1, X 2 is N or C E 1, Q 1 is, wherein each X 11, X 12 and X 13 is equal to C E 11; and any or two of X14, X15 and X16 are N and the others are C E11; R 1 is C 0-10 alkyl, cycloC 3-10 alkyl, bicycloC 5-10 alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl, heterobicycloC 5-10 alkyl, spiroalkyl or heterorospiroalkyl, wherein any of them is optionally substituted with one or more independent G 11 substituents; Each E1, E11, G1 and G41 is independently halo, CF3, OCF3, OR2, NR2R3 (R2a) j1, C (= O) R2, CO2R2, CONR2R3, NO2, CN, S (O) j1R2, SO2NR2R3, NR2C (= O) R3, NR2C (= O) OR3, NR2C (= O) NR3R2a, NR2S (O) j1R3, C (= S) OR2, C (= O) SR2, NR2C (= NR3) NR2aR3a, NR2C (= NR3) OR2a, NR2C (= NR3) SR2a, OC (= O) OR2, OC (= O) NR2R3, OC (= O) SR2, SC (= O) OR2, SC (= O) NR2R3, C0-10alkyl, C2- 10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, C1-10alkylthioC2-10alkynyl, cycloC3-8alkyl cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, cycloC3-8alkylC2-10alkynyl, cycloC3-8alkenylC2-10alkynyl, heterocyclylcylkylcylkylcycloalkyl , wherein any of them is optionally substituted by one or more independent halo, oxo, CF3, OCF3, OR222, NR222R333 (R222a) j1a, C (= O) R222, CO2R222, C (= O) NR222R333, NO2, CN, S (= O) j1 aR222, SO2NR222R333, NR222C (= O) R333, NR222C (= O) OR333, NR222C (= O) NR333R222a, NR222S (O) j1aR333, C (= S) OR222, C (= O) SR222, NR222C NR222aR333a, NR222C (= NR333) OR222a, NR222C (= NR333) SR222a, OC (= O) OR222, OC (= O) NR222R333, OC (= O) SR222, SC (= O) OR222 or SC (= O) NR222 substituents; or E1, E11 or G1 is optionally (W1) n (Y1) m R4; or E1, E11, G1 or G41 are optionally independently aryl C0-10alkyl, aryl C2-10alkenyl, aryl C2-10alkynyl, hetaryl C0-10alkyl, hetaryl C2-10alkenyl or hetaryl C2-10alkynyl, wherein any of them is optionally substituted by one or more independent halo, CF3, OCF3, OR222, NR222R333 (R222a) j2a, C (O) R222, CO2R222, C (= O) NR222R333, NO2, CN, S (O) j2aR222, SO2NR222R333, NR222C (= O) , NR222C (= O) OR333, NR222C, (= O) NR333R222a, NR222S (O) j2aR333, C (= S) OR222, C (= O) SR222, NR222C (= NR333) NR222aR333a, NR222C (= NR33 (= NR333) SR222a, OC (= O) OR222, OC (= O) NR222R333, OC (= O) SR222, SC (= O) OR222 or SC (= O) NR222R333 substituents; G11 is halo, oxo, CF3, OCF3, OR21, NR21R31 (R2a1) j4, C (O) R21, CO2R21, C (= O) NR21R31, NO2, CN, S (O) j4R21, SO2NR21R31, NR21 (C = O) ) R31, NR21C (= O) OR31, NR21C (= O) NR31R2a1, NR21S (O) j4R31, C (= S) OR21, C (= O) SR21, NR21C (= NR31) NR2a1R3a1, NR21C (= NR31) OR2a1 , NR21C (= NR31) SR2a1, OC (= O) OR21, OC (= O) NR21R31, OC (= O) SR21, SC (= O) OR21, SC (= O) NR21R31, P (O) OR21OR31, C1 -10alkylidene, C0-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alk |