| abstract |
An N-hydroxyamide derivative according to Formula (I), wherein A is selected from -C (B) - and N; B is H or B and forms a bond with R5 or R7, R1 is selected from H; C1-C6-alkyl; C2-C6-alkenyl; C2-C6-alkynyl; C3-C8-cycloalkyl, heterocycloalkyl; aryl, heteroaryl, C3-C8 cycloalkyl C1-C6 alkyl, heterocycloalkyl C1-C6-alkyl, heteroaryl C1-C6-alkyl, amino and alkoxy; R2 is selected from H; C1-C6 alkyl, C2-C6 alkenyl; C2-C6 alkynyl; C3-C8-cycloalkyl, heterocycloalkyl; alkoxy, aryl, and heteroaryl; R3 is selected from H, C1-C6 alkyl, C2-C6-alkenyl and C2-C6 alkynyl; R4, R5, R6 and R7 are independently selected from H; C1-C6 alkyl, C2-C6 alkenyl; C2-C6 alkynyl; or R4 and R7 may form the bond -CH2-; n is an integer selected from 1, 2, 3, 4, 5 and 6; Carbon atoms (2) and (3) are two chiral centers, where in the chiral center (2) there is a configuration that can be chosen between "S" and "R", and in the chiral center (3) the configuration is "S" as well as their pharmaceutically acceptable salts. The patent contains another 29 patent claims. |