http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HR-P20080603-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34c531b0dce54fb192c75fd1f4f8d473 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0059 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 |
| filingDate | 2008-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_464a94a73edb8ba0f058613ab7a5ee5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f91071786306bbcca7a1bcba2a7fbdb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad2d4cac21a015e271751e1d3ade80d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e5af1d4a1b97b770cc6d4c0db158f5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_052482d3521e55f048f4d337ef51b017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e18c75d04be646c7990daa14ce8e151 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bfa1fb4d404a2db0171e36c9b9d7099 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4472720cb81b00a45d6e733012ff448 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a54d7de1386a2e3e259af9de4955661 |
| publicationDate | 2009-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HR-P20080603-T3 |
| titleOfInvention | NEW 17beta TYPE I DEHYDROGENASE HYBROXYSTEROID INHIBITORS |
| abstract | A compound of general formula I, wherein (i) X represents: a) a bond, b) -NR3-, oric) -OA represents: a) -CO-, or b) provided that X represents a bond or -NR3-, A represents SO2-, Y represents: a) -NR4-, b) -O-, provided that X represents a bond or -NR3-, c) a bond, d) -NH-SO2-, provided that X represents -NR3 - and A represents -CO-, e) -NH-SO2-NR4-, provided that X represents -O-, or f) -NH-NR4-, provided that X represents a bond; or (ii) -XAY- together represent -O-, and wherein R 1 and R 3 are independently selected from: a) -H, - (C 1 -C 6) alkyl, which is optionally substituted with halogen, nitrile, -OR 6, -SR6, or -COOR6; the number of said substituents would be up to perhalo for halogen, and up to two for any combination of said halogen, nitrile, -OR6, -SR6, -R6 or -COOR6 residues, b) -phenyl, which is optionally substituted with halogen, nitrile, -OR6, -SR6, -R6 or -COOR6; the number of said substituents would be up to perhalo for halogen, and up to two for any combination of said halogen, nitrile, -OR6, -SR6, or -COOR6 residues, c) - (C1-C4) alkyl-phenyl, in which the alkyl content is optionally substituted with up to three halogens; and the phenyl moiety optionally substituted with halogen, nitrile, -OR6, -SR6, -R6 or -COOR6, the number of substituents on said phenyl moiety may be up to perhalo for halogen and up to two for any combination of -OR6, -SR6, R6 or -COOR6 residues; R 2 and R 4 are independently selected from: a) -H, wherein if X represents a bond, A represents -CO- and Y represents -O- or a bond, then R 2 is other than -H; b) - (C1-C12) alkyl, optionally substituted with up to five substituents independently selected from the group consisting of halogen, hydroxyl, thiol, nitrile, alkoxy, aryloxy, arylalkoxy, amino, amido, alkylthio, arylalkylthio, sulfamoyl, sulfonamides, acyl, carboxyl and acylamino, aryl, which aryl is optionally substituted with up to three substituents independently selected from the group consisting of halogen, hydroxyl, (C1-C6) alkoxy, carboxyl- (C1-C6) alkyl, thiol, nitrile, sulfamoyl, aryloxy, arylalkyloxy, - (C1-C6) alkylthio, arylthio, amino, amido, acylamino and heteroaryl; or aryl is optionally substituted by two groups which are joined adjacent carbon atoms ii combined into a saturated or partially saturated cyclic 5, 6, 7, or 8-membered ring system, optionally containing up to three heteroatoms, such as N, O or S, the number of n atoms may be 0-3 and the number of each of the O and S atoms may be 0-2, heteroaryl, which heteroaryl is optionally substituted with up to three substituents independently selected from the group consisting of halogen, hydroxyl, (C1- C6) alkoxy, (C1-C6) alkyl, (C1-C6) alkyl, halogenated - (C1-C6) alkyl, halogenated - (C1-C6) alkoxy, carboxyl- (C1-C6) alkyl, thio, nitrile, sulfamoyl , sulfonamide, carboxyl, aryloxy, arylalkoxy, (C1-C6) alkylthio, arylthio, arylalkylthio, amino, amido, acyl, acylamino, aryl- (C1-C4) -alkyl and aryl; wherein each aryl group is optionally substituted with up to three substituents independently selected from the group consisting of hydroxyl, halogen, (C1-C6) alkoxy |
| priorityDate | 2003-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.