| abstract |
Compound of formula IV, wherein R 1 is alkyl, alkoxy, halogen, COOH, COOalkyl, CN, C (O) N (R 6) 2, or (OCH 2 CH 2) n OCH 3, R 2 alkyl, halogen, alkyl substituted by halogen, OH, alkoxy, alkoxy substituted by halogen, phenyl, N (R6) 2, (OCH2CH2) nOCH3, O (CH2) mNR7R8, or is a 6-membered heterocycle optionally substituted by alkyl or C (O) OR6, or R1 and R2 together form a heterocyclic ring with 5 members; R3 is hydrogen or alkyl; R 4 is hydrogen, halogen, CN, NO 2, alkyl, or alkoxy; each R 6 is independently hydrogen or alkyl; R7 and R8 are each independently hydrogen, alkyl or alkoxyalkyl, or R7 and R8 taken together with the nitrogen atom to which they are attached form a 6-membered heterocycle optionally substituted with alkyl; each n is independently 1, 2, or 3; im is 2, 3, or 4; or a pharmaceutically acceptable salt thereof. The patent contains another 64 patent claims. |