| abstract |
The present invention relates to the use of compounds of formula (I), their N-oxides, pharmaceutically acceptable addition salts, quaternary amines and their stereochemically isomeric forms, in which the formula -a = aa = a- forms phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with a bonded vinyl group, n is 0 to 4, and where possible 5, R is hydrogen, aryl, formyl, C-alkyl carbonyl, C-alkyl, C-alkyloxycarbonyl, substituted C-alkyl, or substituted C-alkyloxy-C Each of R independently represents hydroxy, halogen, optionally substituted C-alkyl, C-alkenyl or C-alkynyl, C-cycloalkyl, C-alkyloxy, C-alkyloxy-carbonyl, carboxyl, cyano, nitro, amino, mono- or di- (C-alkyl) amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) R, -NH-S (= O) R, -C (= O) R, -NHC (= O) H, -C (= O) NHNH, -NHC (= O) R, -C = NH) or a five membered heterocyclic ring, p is 1 or 2, L is optionally substituted C-alkyl, C-alkenyl, C-alkynyl, C -cycloalkyl; or L is -X-R8 where R is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, X is -NR-, -NH-NH-, -N = N-, -O-, -C (= O) -, - CHOH-, -S-, -S (= O) - or -S (= O) -; Q is hydrogen, C-alkyl, halogen, polyhalo-C-alkyl or an optionally substituted amino group; Y represents hydroxy, halogen , C-cycloalkyl, optionally substituted C-alkyl, C-alkenyl or C-alkynyl, C-alkyloxy, C-alkyloxy-carbonyl, carboxyl, cyano, nitro, amino, mono- or di (C-alkyl) amino, polyhalo -methyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) R, -NH-S (= O) R, -C (= O) R, -NHC (= O) H, -C (-O) NHNH, - NHC (= O) R 1 -C (= NH) R 1 aryl, aryl is an optionally substituted phenyl, Het is an optionally substituted heterocyclic radical, for the manufacture of a medicament for the treatment of persons suffering from HIV infection (human immunodeficiency virus) . |