| abstract |
The present invention relates to the use of compounds of formula (I), their N-oxides, pharmaceutically acceptable addition salts, quaternary amines and their stereochemically isomeric forms, in which the formula-a1 = a2-a3 = a4- forms phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with a linked vinyl group; n is 0 to 4, and where possible 5; R 1 is hydrogen, aryl, formyl, C 1-6 alkyl carbonyl, C 1-6 alkyl, C 1-6 alkyloxycarbonyl, substituted C 1-6 alkyl, or substituted C 1-6 alkyloxy-C 1-6 alkylcarbonyl; each of R 2 independently represents hydroxy, halogen, optionally substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, C 3-7 cycloalkyl, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di- (C1-6-alkyl) amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) pR6, -NH-S (= O) pR6, -C O) R 6, -NHC (= O) H, -C (= O) NHNH 2, -NHC (= O) R 6, -C = NH) R 6 or a five membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-7-cycloalkyl; or L is -X-R3 wherein R3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is -NR1-, -NH-NH-, -N = N-, -O-, -C (= O) -, -CHOH-, -S-, -S (= O) - or-S (= O) 2-; Q is hydrogen, C1-6-alkyl, halogen, polyhalo-C1-6-alkyl or an optionally substituted amino group; Y represents hydroxy, halogen, C3-7-cycloalkyl, optionally substituted C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl, C1-6-alkyloxy, C1-6-alkyloxy-carbonyl, carboxyl, cyano , nitro, amino, mono- or di (C1-6-alkyl) amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) pR6, -NH-S (= O) pR6, -C (= O) R 6, -NHC (= O) H, -C (-O) NHNH 2, -NHC (= O) R 6, -C (= NH) R 6 or aryl; aryl is optionally substituted phenyl; Het is an optionally substituted heterocyclic radical; for the manufacture of a medicament for the treatment of persons suffering from HIV infection (human immunodeficiency virus). |