| abstract |
Use of compounds of general formula, wherein R 1 is aryl, unsubstituted or substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, - (CH 2) oOH, -C (O) H, CF 3, CN , S-alkyl, -S (O) 1,2-alkyl, -C (O) NR'R '', -NR'R '', -NR'C (O) -alkyl, -NR'-S ( O) 2-alkyl or heteroaryl is selected from the group consisting of pyridin-2- or 3-yl, imidazolyl or oxazolyl, unsubstituted or substituted by alkyl, halogen or alkoxy; R 2 and R 3 are independently hydrogen, halogen, alkyl, alkoxy, OCHF 2, OCH 2 F, OCF 3 or CF 3, R 4, R 5 are independently hydrogen, - (CR'R '') 1- (CR'R '') 1- (CR'R '') 0,1-OH or- (CR'R '') 1- (CR'R '') 1- (CR'R '') 0,1-alkyl, where R ' and R '' on each carbon atom may be the same or different from each other, -C1,2-alkyl, -C (O) H, - (CH2) cycloalkyl, unsubstituted or substituted by hydroxy, - (CH2) 1,2 , 3NR'R '', - (CH2) 1,2,3NR'C (O) -alkyl, - (CH2) 1,2,3NR'S (O) -alkyl, - (CH2) oS (O) -alkyl, - (CH2) oS-alkyl, - (CH2) oS (O) 2-alkyl; - (CH2) oS (O) 2-NR'R''R 'is hydrogen, alkyl, - (CH2) oOH, -C (O) H, -C (O) -alkyl, -C (O) -cycloalkyl , -S (O) 2-alkyl, -S (O) 2-halogen-alkyl, -S (O) -alkyl, -S-alkyl or -S (O) 2-N- or di-alkyl, R ' 'is hydrogen or alkyl; or R4 and R5 together with the N-atom to which they are attached are a ring with - (CH2) 3-5-, which is unsubstituted or substituted by one or more substituents co-selected from the group consisting of alkyl, halogen, CF3, - (CR'R '') oOH, = O, -CHO, -NR'R '', where R 'and R' 'are as described above or may form together with the N atom to which they are attached a ring with - ( CH2) 3-5 or with - (CH2) oNR'-C (O) -alkyl, - (CH2) oC (O) -alkyl, - (CH2) oC (O) -cycloalkyl, - (CH2) oOC (O ) NR'R '', - (CH2) oS (O) 2-alkyl, - (CH2) oS (O) -alkyl, - (CH2) oS-alkyl, - (CH2) oS (O) 2-NR ' R '', - (CH2) o-pyrrolidinyl or -C (O) NR'R '', or with- (CH2) 1,2,3-NR '- (CH2) 2-, which is unsubstituted or substituted by or more substituents selected from the group consisting of alkyl, halogen, CF3, - (CR'R '') oOH, = O, -CHO, -NR'R '', wherein R 'and R' 'are as is described above or may form together with the N atom to which the ring is attached with - (CH2) 3-5 or with - (CH2) oNR'-C (O) -alkyl, - (CH2) oC (O) -alkyl, - (CH2) oC (O) -cycloalkyl, - (CH2) oOC (O) NR 'R' ', - (CH2) oS (O) 2-alkyl, - (CH2) oS (O) -alkyl, - (CH2) oS-alkyl, - (CH2) oS (O) 2-NR'R' ', - (CH2) o-pyrrolidinyl or -C (O) NR'R' 'or with- (CH2) 1,2,3-O- (CH2) 2-, which is unsubstituted or substituted by one or more substituents which are selected from the group consisting of alkyl, halogen, CF3, - (CR'R '') oOH, = O, -CHO, -NR'R '', wherein R 'and R' 'are as described above or may form together with the N atom to which the ring is attached with - (CH2) 3-5 or with - (CH2) oNR'-C (O) -alkyl, - (CH2) oC (O) -alkyl, - (CH2) ) oC (O) -cycloalkyl, - (CH2) oOC (O) NR'R '', - (CH2) oS (O) 2-alkyl, - (CH2) oS (O) -alkyl, - (CH2) oS -alkyl, - (CH2) oS (O) 2-NR'R '', - (CH2) o-pyrrolidinyl or -C (O) NR'R '' or with- (CH2) 1,2,3-S (O) 0,1,2- (CH2) 1,2,3-, which is unsubstituted or substituted by one or more substituents selected from the group consisting of |