| abstract |
Compound of general formula (1): characterized in that the (CH 2) n C (= O) Q 1 group is in the meta or para position, R 1 and R 2 are independently selected from H and C 1 -C 4 alkyl, n is 0, 1 or 2, and Q1 is a group selected from:, and a group * -NR11-Q2-A, wherein p is 1 or 2, Q2 is C1-C4 alkylene, R11 is H or C1-C4 alkyl, and A is pyridyl, C3-C10 cycloalkyl, wherein said cycloalkyl is optionally bridged with one or more carbon atoms, tetrahydropyranyl, piperidinyl, optionally substituted with benzyl, tetrahydrothiopyranyl or a group wherein R3, R4, R5, R6 and R7 are the same or different and are selected from H, C1-C4 alkyl, OR5, SR9, halogen, CN, CF3, OCF3, COOR9, SO2NR9R10, CONR9R10, NR9R10, NHCOR10 and phenyl; wherein R 8 is C 1 -C 4 alkyl, R 8 and R 10 are the same or different and are selected from H or C 1 -C 4 alkyl, and * represents the point of attachment to the carbonyl group; or, if appropriate, pharmaceutically acceptable salts and (or) isomers, tautomers, solvates or isotopic variants thereof. The patent contains another 32 patent claims. |