| abstract |
The present invention relates to alkaloid reaction products obtainable by a process in which the alkaloids are reacted with an alkylating agent, preferably a steppe, after which the unreacted alkylating agent and other water-soluble compounds are removed from the reaction mixture by rinsing with water or a suitable aqueous solvent. the reaction mixture is subjected to treatment with a strong acid, preferably hydrogen chloride (HCl), to precipitate water-soluble salts of the reaction products. The precipitated reaction products include at least one quaternary alkaloid derivative and are suitable as medicaments for prophylactic or therapeutic purposes, in particular in the treatment of immune or metabolic disorders, and cancer. |