| abstract |
A compound of formula I: wherein: m is 0 or 1; Z represents CN, OR2a, CO2R2a or CON (R2a) 2, R1b represents H, C1-4alkyl or OH; R1c represents H or C1-4alkyl; Ar 1 represents phenyl or pyridyl, wherein any carries 0-3 substituents independently selected from halogen, CN, NO 2, CF 3, OH, OCF 3, C 1-4 alkoxy or C 1-4 alkyl, which optionally carries a substituent selected from halogen, CN, NO 2, CF3, OH and C1-4alkoxy; Ar2 represents phenyl substituted at the 2- and 5-positions by halogen; R 2a represents H, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl C 1-6 alkyl, C 2-6 alkenyl, wherein any optionally carries a substituent selected from halogen, CN, NO 2, CF 3, OR 2b, CO2R 2b, N (R 2b) 2, CON (R2b) 2, Ar and COAr; or R2a represents Ar; or two R 2a groups, together with the nitrogen atom to which they are attached to each other may complete an N-heterocyclyl group bearing 0-4 substituents independently selected from = O, = S, halogen, C 1-4 alkyl, CN, NO 2, CF 3, OH , C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di (C1-4alkyl) amino, carbamoyl, Ar and COAr; R 2b represents H, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl C 1-6 alkyl, C 2-6 alkenyl, wherein any optionally carries a substituent selected from halogen, CN, NO 2, CF 3, OH, C 1-4 alkoxy, C 1-4 alkoxycarbonyl, CO2H , amino, C1-4alkylamino, di (C1-4alkyl) amino, carbamoyl, Ar and COAr; or R2h represents Ar; or two R 2b groups, together with the nitrogen atom to which they are attached to each other may complete an N-heterocyclyl group bearing 0-4 substituents independently selected from = O, = S, halogen, C 1-4 alkyl, CN, NO 2, CF 3, OH , C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di (C1-4alkyl) amino, carbamoyl, Ar and COAr; Ar represents phenyl or heteroaryl bearing 0-3 substituents selected from halogen, C1-4alkyl, CN, NO2, CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, amino, C1-4alkylamino, di (C1-4alkyl) amino, carbamoyl , C1-4alkylcarbamoyl and di (C1-4alkyl) carbamoyl; or a pharmaceutically acceptable salt thereof. The patent contains 13 more patent claims. |