| abstract |
The acylated indanyl amine of the general formula (I) in any stereoisomeric form or mixture thereof in any ratio or a pharmaceutically acceptable salt thereof wherein R 1 and R 4 are independently selected from the group consisting of: H; unsubstituted and at least monosubstituted C1-C10-alkyl, C2-C10-alkenyl and C2-C10-alkynyl, the substituents of which are selected from the group consisting of F, OH, C1-C8-alkoxy, (C1-C8-alkyl) mercapto, CN , COOR6, CONR7R8, and unsubstituted and at least monosubstituted phenyl and heteroaryl, the substituents of which are selected from the group consisting of halogens, pseudohalogens, C1-C3-alkyl, C1-C3-alkoxy and CF3; unsubstituted and at least monosubstituted phenyl and heteroaryl, the substituents of which are selected from the group consisting of halogens, pseudohalogens, C1-C3-alkyl, C1-C3-alkoxy and CF3; R9CO; CONR10R11; COOR12; CF3; halogens; pseudohalogens; NR13R14; OR15; S (O) mR16; SO2NR17R18; and NO2; R2 and R3 are independently selected from the group consisting of: H; halogens; pseudohalogens; unsubstituted and at least monosubstituted C1-C10-alkyl whose substituents are selected from the group consisting of OH, phenyl and heteroaryl; OH; C1-C10-alkoxy; phenoxy; S (O) mR19; CF3; CN; NO2; (C1-C10-alkyl) amino; di (C1-C10-alkyl) amino; (C1-C6-alkyl) -CONH-; unsubstituted and at least monosubstituted phenyl-CONH- and phenyl-SO2-O-, the substituents of which are selected from the group consisting of halogens, pseudohalogens, CH3 and methoxy; (C1-C6-alkyl) SO2-O-; unsubstituted and at least monosubstituted (C1-C6-alkyl) CO, the substituents of which are selected from the group consisting of F, di (C1-C3-alkyl) amino, pyrrolidinyl and piperidinyl; and phenyl-CO, wherein the phenyl moiety may be substituted with one or more substituents from the group consisting of C1-C3-alkyl, halogens and methoxy; A is selected from the group consisting of CH2, CHOH and CH- (C1-C3-alkyl); B is selected from the group consisting of CH2 and CH- (C1-C3-alkyl); R5 is an Ar group or a Hetar group, both of which may be unsubstituted or bear one or more substituents selected from the group consisting of: halogens; pseudohalogens; NH2; unsubstituted and at least monosubstituted C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, C1-C10-alkoxy, (C1-C10-alkyl) amino and di (C1-C10-alkyl) amino, whose substituents are selected from the group consisting of F, OH, C1-C8-alkoxy, aryloxy, (C1-C8-alkyl) -mercapto, NH2, (C1-C8-alkyl) amino and di (C1-C8-alkyl) amino; C3-C5-alkanediyl; phenyl; heteroaryl; aryl- or heteroaryl-substituted C1-C4-alkyl; CF3; NO2; OH; phenoxy; benzyloxy; (C1-C10-alkyl) COO; S (O) mR20; SH; phenylamino; benzylamino; (C1-C10-alkyl) -CONH-; (C1-C10-alkyl) -CON (C1-C4-alkyl) -; phenyl-CONH-; phenyl-CON (C1-C4-alkyl) -; heteroaryl-CONH-; heteroaryl-CON (C1-C4-alkyl) -; (C1-C10-alkyl) -CO; phenyl-CO; heteroaryl-CO; CF3-CO; -OCH2O-; -OCF2O-; -OCH2CH2O-; -CH2CH2O-; COOR21; CONR22R23; CNH (NH2); SO2NR24R25; R26SO2NH-; R27SO2N (C1-C6-alkyl) -; and saturated and at least monounsaturated aliphatic, mononuclear 5- to 7-membered heterocycles containing 1 to 3 heteroatoms selected from the group consisting of N, O and S, and said heterocycles may |