| abstract |
Compound of formula (I), salt or hydrate thereof: the symbols have the following meanings and are independently selected at each occurrence: G is an aryl or heterocyclo group, said group being mono- or polycyclic and optionally substituted on one or more multiple positions; L is a bond, (CR7R7) n (wherein n is 1 and R7 and R7 are independently H, alkyl or substituted alkyl) or -CH2-NH-, A1 and A2 are each independently CR7, at wherein R 7 (i) represents hydrogen, alkyl or substituted alkyl, arylalkyl or substituted arylalkyl, alkenyl or substituted alkenyl, aryl or substituted aryl, heterocyclo or substituted heterocyclo, heterocycloalkyl or substituted heterocycloalkyl, wherein for each substituent one or more groups selected from V , or (ii) form, together with R7 is a group W, a heterocyclic ring; V1 is OH, CN, halo, -O-aryl, -O-substituted aryl, -O-heterocyclo, -O-substituted heterocyclo, -O-CO-alkyl, -O-CO-substituted alkyl, -O- (alkylsilyl ), -O-arylalkyl, -O-substituted arylalkyl, -O-CO-substituted arylalkyl, -O-CO-aryl, -O-CO-substituted aryl, -O-CO-heterocyclo, -O-CO-substituted heterocyclo , -S- (optionally substituted aryl) -NH-CO- (optionally substituted alkyl), -SO- (optionally substituted aryl) -NH-CO- (optionally substituted alkyl), -SO2- aryl) -NH-CO- (optionally substituted alkyl), -NH-SO2-aryl, -NH-SO2-substituted aryl, -NH-CO-O- (optionally substituted arylalkyl), -NH-CO-O- alkyl, -NH-CO-O-substituted alkyl, -NH-CO-alkyl, -NH-CO-substituted alkyl, -NH-CO-aryl, -NH-CO-substituted aryl, -NH-CO- (optional substituted arylalkyl), -NH-CO- (optionally substituted alkyl) -O- (optionally substituted aryl), -N (optionally substituted alkyl) (optionally substituted aryl), -N (optionally substituted alkyl) optionally substituted aryl alkyl), -COH, -COOH, -CO-O-alkyl, -CO-O-substituted alkyl, -CO-O- optionally substituted arylalkyl, -CO-aryl, -CO-substituted aryl, -O-CO- NH-aryl, -O-CO-NH-substituted aryl, -CO-NH-aryl, -CO-NH-substituted aryl, -CO-NH-arylalkyl, -CO-NH-substituted arylalkyl or -O- (optional substituted aryl) -NH-CO- (optionally substituted alkyl); Y represents -O-, -SO-, -N (V2) -, -CH2-N (V2) -, -CO-N (alkyl) -, -CH2S- or -CH2-SO2, V2 represents hydrogen, alkyl, arylakyl, -CO-alkyl, -CO-O-aryl or -CO-O-arylalkyl; Z1 and Z2 represent O; Q1, and Q2 represent H; W represents CR7R7'-CR7R7 ', CR7R7'-C = O, NR9 -CR7R7', N = CR8, N = N, NR9 -NR9 ', cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, or aryl or substituted aryl, provided that when W is not NR9 - CR7R7, N = CR8, N = N, NR9 - NR9 ', or heterocyclo or substituted heterocyclo, then Y must be -O-, -CH2-S-, -SO-, -CH2-SO2-, N (V2) - or -CH2-N (V2), R1 and R1 each independently represent H, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloa |