| abstract |
Compound of formula I, wherein R (1) is C (O) OR (9), SO 2 R (10), COR (11), C (O) NR (12) R (13) or C (S) NR ( 12) R (13); R (9) is CxH2x-R (14); x is 0, 1, 2, 3 or 4, where x cannot be 0 if R (14) represents 0R (15) or SO2Me; R (14) is alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbon atoms, CF3, C2F5 , C3F7, CH2F, CHF2, OR (15), SO2Me, phenyl, naphthyl, biphenylyl, furyl, thienyl or heteroaromatic containing N having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, wherein the phenyl, naphthyl, biphenylyl, furyl, thienyl and N-containing heteroaromate are unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, J, CF3, OCF3, NO2, CN, COOMe , CONH2, COMe, NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; R (15) is alkyl having 1, 2, 3, 4 or 5 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, CF3 or phenyl which is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, J, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 C-atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; R (10), R (11) and R (12) are independently defined as R (9); R (13) is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or CF3, R (2) is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms or CF3, R (3) is CyH2y -R (16); y is 0, 1, 2, 3 or 4, wherein y cannot be 0 if R (16) is OR (17) or SO2Me; R (16) is alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms, cycloalkyl having 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbon atoms, CF3, C2F5 , C3F7, CH2F, CHF2, OR (17), SO2Me, phenyl, naphthyl, furyl, thienyl or heteroaromatic containing N having 1, 2, 3, 4, 5, 6, 7, 8 or 9 carbon atoms, wherein phenyl, naphthyl, furyl, thienyl and N-containing heteroaromate are unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, J, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe , NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; R (17) is hydrogen, alkyl having 1, 2, 3, 4 or 5 carbon atoms, cycloalkyl having 3, 4, 5 or 6 carbon atoms, CF3, phenyl or 2-, 3- or 4-pyridyl, at wherein the phenyl or 2-, 3- or 4-pyridyl is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, J, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe , NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; or R (3) is CHR (18) R (19); R (18) is hydrogen or CzH2z-R (16), wherein R (16) is as defined above; z is 0, 1, 2 or 3; R (19) is COOH, CONH2, CONR (20) R (21), COOR (22), CH2OH; R (20) is hydrogen, alkyl having 1, 2, 3, 4 or 5 carbon atoms, CvH2v-CF3 or CwH2w-phenyl, the phenyl ring being unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of consists of F, Cl, Br, J, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkox |