abstract |
A compound of the formula [region] - [region] - [region] - [region] (I) or a pharmaceutically acceptable salt thereof, wherein [region] is a whole of the formula where the symbol "*" denotes the binding point of the whole of formula (2.0.0) for R4 is H or C1-C2 alkyl; R 6 is H, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, -CN, -OH or -CONH 2, A is phenyl, optionally substituted with up to 4 substituents independently selected from fluoro, chloro, -CO 2 R 4, -OH, -CN , -CONR4aR4b, -NR4aR4b, -NR4aCOR4b, -NR4aCO2R4b, -NR4aS (O) pR4b, -S (O) pNR4aR4b, C1-C4 alkyl, C1-C4 alkoxy, C1-C2 alkoxycarbonyl alkylcarbonyloxy, wherein said C1-C4 alkyl and C1-C4 alkoxy may be optionally substituted with up to 3 substituents independently selected from fluoro and chloro; p is 0, 1 or 2; R4a and R4b are, each independently, H or C1-C2 alkyl; R5a is a direct bond, -CO- or -SO2-, W1 is (i) a direct bond, or (ii) when R5a is -CO- or -SO2-, C1-C3 alkylene, optionally substituted with up to two R23 substituents, or (iii) an entity independently selected from formulas (2.0.6) to (2.0.16) inclusive; where the symbol "" denotes the point of attachment of the whole W1 to the nitrogen atom in the partial formula (2.0.0), and the symbol "*" denotes the point of attachment of the whole W1 to the other, remaining parts of the partial formula (2.0.0); R23 is fluoro, chloro, -CO2R4, -OH, -CN, C1-C4 alkoxy, C3-C7 cycloalkyl or phenyl, said C1-C4 alkoxy, C3-C7 cycloalkyl and phenyl optionally substituted with up to two R11 substituents R11 is fluoro, chloro, -CO2R4, -OH, -CN, -CONR4aR4b, -NR4aR4b, -NR4aCOR4b, -NR4aCO2R4b, -NR4aS (O) pR4b, -S (O) pNR4aR4b, alkyl, C1-C C1-C4 alkoxy, C1-C2 alkoxycarbonyl, C1-C2 alkylcarbonyl and C1-C2 alkylcarbonyloxy, wherein said C1-C4 alkyl and C1-C4 alkoxy may be optionally substituted with up to 3 substituents independently selected from fluoro and chloro; R24 is H or C1-C4 alkyl; R 25 and R 26 are each independently -OH, C 1 -C 2 alkyl or C 1 -C 2 alkoxy, said C 1 -C 2 alkyl being optionally substituted with up to 3 substituents selected from fluoro and -OH; R27 is (i) C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with up to 3 substituents R28; or (ii) - (CH2) n- (C3-C7 cycloalkyl), wherein: (a) said C3-C7 cycloalkyl is optionally substituted with up to 3 R28 substituents, (b) n is 0, 1 or 2, (c) ) in the case of n = O, the carbon of said C3-C7 cycloalkyl is optionally substituted with one substituent selected from C1-C4 alkyl and phenyl, and said C1-C4 alkyl and phenyl are optionally substituted with 1 or 2 substituents selected from -CH3, -OCH3, -OH or -NH2; and (d) in the case of n = 1 or 2, the resulting methylene or ethylene is optionally substituted by one substituent selected from fluoro, -NH2, -N (CH3) n, -OH, -OCH3, C1-C4 alkyl or phenyl , wherein said C 1 -C 4 alkyl and phenyl are optionally substituted with 1 or 2 substituents selected from -CH 3, -OCH 3, -OH or -NH 2; or (iii) phenyl, furyl, tetrahydrofuranyl, tetrahydropyranyl, oxetanyl, thienyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, thiazole |