http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HR-P20010453-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 |
| filingDate | 2001-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26ed63498df2f132abcd2844e74e774d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df89ad17efbbbb2caf93ae1dd5fca42a |
| publicationDate | 2010-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HR-P20010453-B1 |
| titleOfInvention | ANTIHISTAMINE SPIRO COMPOUNDS |
| abstract | Compound of formula (I) N-oxide, addition salt, quaternary amine and stereochemically isomeric form, wherein R 1 is hydrogen, C 1-6 alkyl, halo, formyl, carboxyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyl, N (R3R4) C (= O) -, N (R3R4) C (= O) N (R5) -, ethenyl substituted with carboxyl or C1-6-alkyloxycarbonyl, or C1-6-alkyl substituted with hydroxy, carboxyl, C1 -6-alkyloxy, C1-6-alkyloxy-carbonyl, N (R3R4) C (= O) -, C1-6-alkyl-C (= O) N (R5) -, C1-6-alkyl-S (O2 ) N (R5) - or N (R3R4) C (= O) (R5) -, wherein each R3 and each R4 independently represent hydrogen or C1-4-alkyl; R5 is hydrogen or hydroxy; R 2 is hydrogen, C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 1-6 alkyloxy-C 1-6 alkyl, N (R 3 R 4) C (= O), aryl or halo; n is 1 or 2; -A-B- represents a divalent radical of formula-Y-CH = CH- (a-1); -CH = CH-Y- (a-2); or -CH = CH-CH = CH- (a-3); wherein each hydrogen atom in the radicals (a-1) to (a-3) may be independently replaced by R6, wherein R6 is selected from the group consisting of C1-6-alkyl, halo, hydroxy, C1-6-alkyloxy, ethenyl substituted with carboxyl or C1-6 alkyloxycarbonyl, hydroxy-C1-6-alkyl, formyl, carboxyl and hydroxycarbonyl-C1-6-alkyl; each Y independently represents a divalent radical of formula -O-, -S- or -NR7-; wherein R7 represents hydrogen, C1-6-alkyl or C1-6-alkylcarbonyl; Z is a divalent radical of formula- (CH2) p- (b-1), -CH = CH- (b-2), -CH2-CHOH- (b-3), -CH2-O- (b-4), -CH2-C (= O) - (b-5), or-CH2-C (= NOH) - (b-6), provided that the divalent radicals (b-3), (b-4), ( b-5) and (b-6) are attached to the nitrogen of the imidazole ring via their -CH2- group; where 1 is 2, 2, 3 or 4; L is hydrogen; C1-6 alkyl; C2-6 alkenyl; C1-6 alkylcarbonyl; C1-6 alkyloxycarbonyl; C1-6-alkyl substituted with one or more substituents each independently selected from the group consisting of hydroxy, carboxyl, C1-6-alkyloxy, C1-6-alkyloxycarbonyl, aryl, aryloxy, cyano or R8HN-, wherein R8 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, C1-6 alkylcarbonyl; or L represents a radical of the formula-Alk-Y-Het1 (c-1), -Alk-NH-CO-Het2 (c-2) or-Alk-Het3 (c-3); wherein Alk represents C1-4-alkanediyl; Y represents O, S or NH; each of Het1, Het2 and Het3 represents furanyl, tetrahydrofuranyl, thienyl, oxazolyl, thiazolyl or imidazolyl each of which is optionally substituted with one or two C1-4-alkyl substituents; pyrrolyl or pyrazolyl optionally substituted with formyl, hydroxy-C1-4-alkyl, hydroxycarbonyl, C1-4-alkyloxycarbonyl or with one or two C1-4-alkyl substituents; thiadiazolyl or oxadiazolyl optionally substituted with amino or C1-4 alkyl; pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl each optionally substituted with C1-4-alkyl, C1-4-alkyloxy, amino, hydroxy or halo; iHet3 may also represent 4,5-dihydro-5-oxo-1H-tetrazolyl substituted with C1-4-alkyl, 2-oxo-3-ox-azolidinyl, 2,3-dihydro-2-oxo-1H-benzimidazol-1 -yl or a radical of formula wherein A-Z represents S-CH = CH, S-CH2-CH2, S-CH2-CH2-CH2, CH = CH-CH = CH, or CH2-CH2-CH2-CH2, aryl is phenyl or phenyl substituted with 1, |
| priorityDate | 1998-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.