http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HR-P20010161-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-80 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2001-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_365d6c008ac0e8dce16ca0477eba79ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39c877cd5f3e3d1693817ca5555b717a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23da23cc5f6b0fd065a1d7704b76836d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ad34b861ad2e616348197a155504f17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d851b47ee9ab8b683a186718049ba056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd353bc9b009350567061c9d0ce4b4a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ea1b420cb8f38ead140ed465124a0bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c993519c4cc61aaa2920228e533f50eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3ccb0d84506e3b24880608cb3e4010a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7757ef2d4bf123ae90dbdd758418436c |
| publicationDate | 2009-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HR-P20010161-B1 |
| titleOfInvention | PYRIMIDINES WHICH INHIBIT HIV REPLICATION |
| abstract | A compound of the formula N-oxides, addition salts, quaternary amines and stereochemically isomeric forms thereof, wherein 0 is 1, 1, 2, 3 or 4; R 1 is hydrogen, aryl, formyl, C 1-6 alkylcarbonyl, C 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyl substituted with formyl, C 1-6 alkylcarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 -alkylcarbonyloxy; C1-6-alkyloxy-C1-6-alkylcarbonyl substituted with C1-6-alkyloxycarbonyl; R2a is cyano, aminocarbonyl, mono- or di (methyl) -aminocarbonyl, C1-6-alkyl substituted with cyano, amino-carbonyl or mono- or di- (methyl) aminocarbonyl, C2-6-alkenyl substituted with cyano, or C2- 6-alkynyl substituted with cyano; each R 2 independently represents hydroxy, halogen, C 1-6 alkyl optionally substituted with cyano or -C (= O) R 6, C 3-7 cycloalkyl, C 2-6 alkenyl optionally substituted with one or more halogen atoms or cyano, C2-6-alkynyl optionally substituted with one or more halogen atoms or cyano, C1-6-alkyloxy, C1-6-alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di (C1-6-alkyl) amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) PR6, -NH-S (= O) PR6, -C (= O) R6, -NHC (= O) H, -C (= O) NHNH2, -NHC (= O) R 6, -C (= NH) R 6 or a radical of formula wherein each A independently represents N, CH or CR 6, B is NH, O, S or NR 6, p is 1 or 2; iR6 is methyl, amino, mono- or dimethylamino or polyhalomethyl; L is C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-7-cycloalkyl, each of said aliphatic groups being substituted with one or two substituents independently selected from the group consisting of * C3- 7-cycloalkyl, * indolyl or isoindolyl, each optionally substituted with one, two, three or four substituents each independently selected from the group consisting of halogen, C1-6-alkyl, hydroxy, C1-6-alkyloxy, cyano, aminocarbonyl, nitro, amino, polyhalomethyl, polyhalo methyloxy and C1-6-alkylcarbonyl, * phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, each of said aromatic rings being optionally substituted with one, two, three, four or five substituents each of which is independently selected from the substituents defined in R2; or L is -X-R3 wherein R3 represents phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, each of said aromatic rings being optionally substituted with one, two, three, four or five substituents each independently selected from substituents defined by in R2; iX is -NR1-, -NH-NH-, -N = N-, -O-, -C (= O) -, -CHOH-, -S-, -S (= O) - or -S (= O) 2S; Q represents hydrogen, C1-6-alkyl, halogen, polyhalo-C1-6-alkyl or -NR4R5; iR4 and R5 are independently selected from the group consisting of hydrogen, hydroxy, C1-12-alkyl, C1-12-alkyloxy, C1-12-alkylcarbonyl, C1-12-alkyloxycarbonyl, aryl, amino, mono- or di (C1- 12-alkyl) amino, mono- or di (C1-12-alkyl) aminocarbonyl, wherein each of the abovementioned C1-12-alkyl groups may be optionally and individually substituted with one or two substituents, each of which is |
| priorityDate | 1998-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 57.